| 1 | |  Ajax Amsterdam | 34 | 28 | 4 | 2 | 102 | 23 | 79 | 88 | B19:45 | 22/04/21 | R 21  Ajax Amsterdam 1 FC Utrecht 1 G15:30 | 25/04/21 | R 30 Ajax Amsterdam 2 AZ Alkmaar 0 G15:30 | 02/05/21 | R 31 Ajax Amsterdam 4 FC Emmen 0 G15:30 | 09/05/21 | R 32 Feyenoord Rotterdam 0 Ajax Amsterdam 3 G15:30 | 13/05/21 | R 33 Ajax Amsterdam 3 VVV Venlo 1 G15:30 | 16/05/21 | R 34 Vitesse Arnhem 1 Ajax Amsterdam 3 |
| 2 | |  PSV Eindhoven | 34 | 21 | 9 | 4 | 74 | 35 | 39 | 72 | G15:30 | 11/04/21 | R 29 VVV Venlo 0 PSV Eindhoven 2 G19:45 | 24/04/21 | R 30 PSV Eindhoven 1 FC Groningen 0 B17:45 | 02/05/21 | R 31 PSV Eindhoven 2 SC Heerenveen 2 G17:45 | 09/05/21 | R 32 Willem II Tilburg 0 PSV Eindhoven 2 G15:30 | 13/05/21 | R 33 PSV Eindhoven 4 PEC Zwolle 2 B15:30 | 16/05/21 | R 34 FC Utrecht 1 PSV Eindhoven 1 |
| 3 | |  AZ Alkmaar | 34 | 21 | 8 | 5 | 75 | 41 | 34 | 71 | G21:00 | 10/04/21 | R 29 AZ Alkmaar 2 Sparta Rotterdam 0 M15:30 | 25/04/21 | R 30 Ajax Amsterdam 2 AZ Alkmaar 0 G21:00 | 01/05/21 | R 31 RKC Waalwijk 1 AZ Alkmaar 3 G21:00 | 08/05/21 | R 32 AZ Alkmaar 1 Fortuna Sittard 0 B15:30 | 13/05/21 | R 33 FC Groningen 0 AZ Alkmaar 0 G15:30 | 16/05/21 | R 34 AZ Alkmaar 5 Heracles Almelo 0 |
| 4 | |  Vitesse Arnhem | 34 | 18 | 7 | 9 | 52 | 38 | 14 | 61 | B21:00 | 09/04/21 | R 29 Vitesse Arnhem 0 ADO Den Haag 0 B17:45 | 25/04/21 | R 30 Feyenoord Rotterdam 0 Vitesse Arnhem 0 G21:00 | 01/05/21 | R 31 Vitesse Arnhem 2 PEC Zwolle 1 M21:00 | 07/05/21 | R 32 Sparta Rotterdam 3 Vitesse Arnhem 0 B15:30 | 13/05/21 | R 33 Fortuna Sittard 3 Vitesse Arnhem 3 M15:30 | 16/05/21 | R 34 Vitesse Arnhem 1 Ajax Amsterdam 3 |
| 5 | |  Feyenoord Rotterdam | 34 | 16 | 11 | 7 | 64 | 36 | 28 | 59 | M13:15 | 02/05/21 | R 31 ADO Den Haag 3 Feyenoord Rotterdam 2 M15:30 | 09/05/21 | R 32 Feyenoord Rotterdam 0 Ajax Amsterdam 3 B15:30 | 13/05/21 | R 33 Heracles Almelo 1 Feyenoord Rotterdam 1 G15:30 | 16/05/21 | R 34 Feyenoord Rotterdam 3 RKC Waalwijk 0 G22:00 | 19/05/21 | R semifinal Feyenoord Rotterdam 2 Sparta Rotterdam 0 G13:15 | 23/05/21 | R final Feyenoord Rotterdam 2 FC Utrecht 0 |
| 6 | |  FC Utrecht | 34 | 13 | 14 | 7 | 52 | 41 | 11 | 53 | G22:00 | 01/05/21 | R 31 FC Utrecht 3 Willem II Tilburg 2 B19:45 | 08/05/21 | R 32 SC Heerenveen 0 FC Utrecht 0 B15:30 | 13/05/21 | R 33 Sparta Rotterdam 0 FC Utrecht 0 B15:30 | 16/05/21 | R 34 FC Utrecht 1 PSV Eindhoven 1 G19:45 | 19/05/21 | R semifinal FC Utrecht 1 FC Groningen 0 M13:15 | 23/05/21 | R final Feyenoord Rotterdam 2 FC Utrecht 0 |
| 7 | |  FC Groningen | 34 | 14 | 8 | 12 | 40 | 37 | 3 | 50 | M19:45 | 24/04/21 | R 30 PSV Eindhoven 1 FC Groningen 0 M15:30 | 02/05/21 | R 31 FC Groningen 1 Sparta Rotterdam 2 G13:15 | 09/05/21 | R 32 FC Emmen 0 FC Groningen 4 B15:30 | 13/05/21 | R 33 FC Groningen 0 AZ Alkmaar 0 M15:30 | 16/05/21 | R 34 PEC Zwolle 1 FC Groningen 0 M19:45 | 19/05/21 | R semifinal FC Utrecht 1 FC Groningen 0 |
| 8 | |  Sparta Rotterdam | 34 | 13 | 8 | 13 | 49 | 48 | 1 | 47 | G19:45 | 24/04/21 | R 30 Sparta Rotterdam 2 VVV Venlo 0 G15:30 | 02/05/21 | R 31 FC Groningen 1 Sparta Rotterdam 2 G21:00 | 07/05/21 | R 32 Sparta Rotterdam 3 Vitesse Arnhem 0 B15:30 | 13/05/21 | R 33 Sparta Rotterdam 0 FC Utrecht 0 G15:30 | 16/05/21 | R 34 SC Heerenveen 1 Sparta Rotterdam 2 M22:00 | 19/05/21 | R semifinal Feyenoord Rotterdam 2 Sparta Rotterdam 0 |
| 9 | |  Heracles Almelo | 34 | 12 | 8 | 14 | 42 | 53 | -11 | 44 | G19:45 | 10/04/21 | R 29 Heracles Almelo 4 Willem II Tilburg 0 M13:15 | 25/04/21 | R 30 FC Emmen 3 Heracles Almelo 1 G17:30 | 01/05/21 | R 31 Heracles Almelo 4 VVV Venlo 0 B17:30 | 08/05/21 | R 32 FC Twente Enschede 1 Heracles Almelo 1 B15:30 | 13/05/21 | R 33 Heracles Almelo 1 Feyenoord Rotterdam 1 M15:30 | 16/05/21 | R 34 AZ Alkmaar 5 Heracles Almelo 0 |
| 10 | |  FC Twente Enschede | 34 | 10 | 11 | 13 | 48 | 50 | -2 | 41 | M22:00 | 10/04/21 | R 29 PEC Zwolle 1 FC Twente Enschede 0 M17:45 | 25/04/21 | R 30 FC Twente Enschede 1 FC Utrecht 2 M19:45 | 01/05/21 | R 31 Fortuna Sittard 3 FC Twente Enschede 0 B17:30 | 08/05/21 | R 32 FC Twente Enschede 1 Heracles Almelo 1 M15:30 | 13/05/21 | R 33 RKC Waalwijk 2 FC Twente Enschede 1 G15:30 | 16/05/21 | R 34 FC Twente Enschede 3 ADO Den Haag 2 |
| 11 | |  Fortuna Sittard | 34 | 12 | 5 | 17 | 50 | 58 | -8 | 41 | M21:00 | 10/04/21 | R 29 Fortuna Sittard 1 FC Emmen 3 G15:30 | 25/04/21 | R 30 ADO Den Haag 0 Fortuna Sittard 3 G19:45 | 01/05/21 | R 31 Fortuna Sittard 3 FC Twente Enschede 0 M21:00 | 08/05/21 | R 32 AZ Alkmaar 1 Fortuna Sittard 0 B15:30 | 13/05/21 | R 33 Fortuna Sittard 3 Vitesse Arnhem 3 M15:30 | 16/05/21 | R 34 Willem II Tilburg 2 Fortuna Sittard 1 |
| 12 | |  SC Heerenveen | 34 | 9 | 12 | 13 | 43 | 49 | -6 | 39 | G15:30 | 11/04/21 | R 29 FC Groningen 0 SC Heerenveen 2 M17:30 | 24/04/21 | R 30 SC Heerenveen 0 PEC Zwolle 2 B17:45 | 02/05/21 | R 31 PSV Eindhoven 2 SC Heerenveen 2 B19:45 | 08/05/21 | R 32 SC Heerenveen 0 FC Utrecht 0 M15:30 | 13/05/21 | R 33 FC Emmen 3 SC Heerenveen 1 M15:30 | 16/05/21 | R 34 SC Heerenveen 1 Sparta Rotterdam 2 |
| 13 | |  PEC Zwolle | 34 | 9 | 11 | 14 | 44 | 53 | -9 | 38 | G22:00 | 10/04/21 | R 29 PEC Zwolle 1 FC Twente Enschede 0 G17:30 | 24/04/21 | R 30 SC Heerenveen 0 PEC Zwolle 2 M21:00 | 01/05/21 | R 31 Vitesse Arnhem 2 PEC Zwolle 1 M15:30 | 09/05/21 | R 32 PEC Zwolle 0 ADO Den Haag 1 M15:30 | 13/05/21 | R 33 PSV Eindhoven 4 PEC Zwolle 2 G15:30 | 16/05/21 | R 34 PEC Zwolle 1 FC Groningen 0 |
| 14 | |  Willem II Tilburg | 34 | 8 | 7 | 19 | 40 | 68 | -28 | 31 | M19:45 | 10/04/21 | R 29 Heracles Almelo 4 Willem II Tilburg 0 G19:45 | 23/04/21 | R 30 Willem II Tilburg 1 RKC Waalwijk 0 M22:00 | 01/05/21 | R 31 FC Utrecht 3 Willem II Tilburg 2 M17:45 | 09/05/21 | R 32 Willem II Tilburg 0 PSV Eindhoven 2 G15:30 | 13/05/21 | R 33 ADO Den Haag 1 Willem II Tilburg 4 G15:30 | 16/05/21 | R 34 Willem II Tilburg 2 Fortuna Sittard 1 |
| 15 | |  RKC Waalwijk | 34 | 7 | 9 | 18 | 33 | 55 | -22 | 30 | M17:45 | 11/04/21 | R 29 RKC Waalwijk 0 Ajax Amsterdam 1 M19:45 | 23/04/21 | R 30 Willem II Tilburg 1 RKC Waalwijk 0 M21:00 | 01/05/21 | R 31 RKC Waalwijk 1 AZ Alkmaar 3 B22:00 | 08/05/21 | R 32 VVV Venlo 3 RKC Waalwijk 3 G15:30 | 13/05/21 | R 33 RKC Waalwijk 2 FC Twente Enschede 1 M15:30 | 16/05/21 | R 34 Feyenoord Rotterdam 3 RKC Waalwijk 0 |
| 16 | |  FC Emmen | 34 | 7 | 9 | 18 | 40 | 68 | -28 | 30 | G13:15 | 25/04/21 | R 30 FC Emmen 3 Heracles Almelo 1 M15:30 | 02/05/21 | R 31 Ajax Amsterdam 4 FC Emmen 0 M13:15 | 09/05/21 | R 32 FC Emmen 0 FC Groningen 4 G15:30 | 13/05/21 | R 33 FC Emmen 3 SC Heerenveen 1 G15:30 | 16/05/21 | R 34 VVV Venlo 0 FC Emmen 4 M22:00 | 20/05/21 | R semifinal FC Emmen (3) 1 NAC Breda (4) 1 |
| 17 | |  VVV Venlo | 34 | 6 | 5 | 23 | 43 | 91 | -48 | 23 | M15:30 | 11/04/21 | R 29 VVV Venlo 0 PSV Eindhoven 2 M19:45 | 24/04/21 | R 30 Sparta Rotterdam 2 VVV Venlo 0 M17:30 | 01/05/21 | R 31 Heracles Almelo 4 VVV Venlo 0 B22:00 | 08/05/21 | R 32 VVV Venlo 3 RKC Waalwijk 3 M15:30 | 13/05/21 | R 33 Ajax Amsterdam 3 VVV Venlo 1 M15:30 | 16/05/21 | R 34 VVV Venlo 0 FC Emmen 4 |
| 18 | |  ADO Den Haag | 34 | 4 | 10 | 20 | 29 | 76 | -47 | 22 | B21:00 | 09/04/21 | R 29 Vitesse Arnhem 0 ADO Den Haag 0 M15:30 | 25/04/21 | R 30 ADO Den Haag 0 Fortuna Sittard 3 G13:15 | 02/05/21 | R 31 ADO Den Haag 3 Feyenoord Rotterdam 2 G15:30 | 09/05/21 | R 32 PEC Zwolle 0 ADO Den Haag 1 M15:30 | 13/05/21 | R 33 ADO Den Haag 1 Willem II Tilburg 4 M15:30 | 16/05/21 | R 34 FC Twente Enschede 3 ADO Den Haag 2 |
