| 1 | |  FK Zenit St Petersburg | 30 | 19 | 8 | 3 | 76 | 26 | 50 | 65 | G16:30 | 11/04/21 | R 25  FK Sochi 1 FK Zenit St Petersburg 2 B19:00 | 17/04/21 | R 26 FK Krasnodar 2 FK Zenit St Petersburg 2 G16:30 | 24/04/21 | R 27 FK Zenit St Petersburg 6 SK Rotor 0 G19:00 | 02/05/21 | R 28 FK Zenit St Petersburg 6 FK Lokomotiv Moskova 1 B14:00 | 08/05/21 | R 29 FK Ufa 0 FK Zenit St Petersburg 0 G14:00 | 16/05/21 | R 30 FK Tambov 1 FK Zenit St Petersburg 5 |
| 2 | |  FK Spartak Moskova | 30 | 17 | 6 | 7 | 56 | 37 | 19 | 57 | M19:00 | 11/04/21 | R 25 FK Lokomotiv Moskova 2 FK Spartak Moskova 0 M19:00 | 18/04/21 | R 26 FK Spartak Moskova 0 FK Ufa 3 G16:30 | 25/04/21 | R 27 FK Spartak Moskova 1 CSKA Moskova 0 G16:30 | 03/05/21 | R 28 PFK Arsenal Tula 1 FK Spartak Moskova 2 G19:00 | 10/05/21 | R 29 FK Spartak Moskova 2 FK Khimki 1 B14:00 | 16/05/21 | R 30 RFK Akhmat Grozny 2 FK Spartak Moskova 2 |
| 3 | |  FK Lokomotiv Moskova | 30 | 17 | 5 | 8 | 45 | 35 | 10 | 56 | G19:00 | 11/04/21 | R 25 FK Lokomotiv Moskova 2 FK Spartak Moskova 0 G16:30 | 17/04/21 | R 26 FK Lokomotiv Moskova 4 FK Rostov 1 G19:00 | 24/04/21 | R 27 FK Tambov 2 FK Lokomotiv Moskova 5 M19:00 | 02/05/21 | R 28 FK Zenit St Petersburg 6 FK Lokomotiv Moskova 1 B16:30 | 08/05/21 | R 29 FK Lokomotiv Moskova 0 FK Dinamo Moscow 0 G14:00 | 16/05/21 | R 30 FK Lokomotiv Moskova 1 Ural Ekaterinburg 0 |
| 4 | |  FK Rubin Kazan | 30 | 16 | 5 | 9 | 42 | 33 | 9 | 53 | G19:00 | 10/04/21 | R 25 FK Rostov 0 FK Rubin Kazan 1 G12:00 | 18/04/21 | R 26 Ural Ekaterinburg 0 FK Rubin Kazan 1 M19:00 | 25/04/21 | R 27 FK Rubin Kazan 0 FK Krasnodar 1 G14:00 | 01/05/21 | R 28 FK Rubin Kazan 2 FK Dinamo Moscow 0 G16:30 | 08/05/21 | R 29 PFK Arsenal Tula 2 FK Rubin Kazan 4 B14:00 | 16/05/21 | R 30 FK Rubin Kazan 1 SK Rotor 1 |
| 5 | |  FK Sochi | 30 | 15 | 8 | 7 | 49 | 33 | 16 | 53 | M16:30 | 11/04/21 | R 25 FK Sochi 1 FK Zenit St Petersburg 2 G16:30 | 18/04/21 | R 26 FK Sochi 2 CSKA Moskova 1 G14:00 | 25/04/21 | R 27 FK Ufa 2 FK Sochi 3 G19:00 | 01/05/21 | R 28 FK Krasnodar 1 FK Sochi 3 G20:00 | 07/05/21 | R 29 FK Sochi 2 SK Rotor 1 B14:00 | 16/05/21 | R 30 FK Khimki 0 FK Sochi 0 |
| 6 | |  CSKA Moskova | 30 | 15 | 5 | 10 | 51 | 33 | 18 | 50 | G19:00 | 12/04/21 | R 25 CSKA Moskova 2 SK Rotor 0 M16:30 | 18/04/21 | R 26 FK Sochi 2 CSKA Moskova 1 M16:30 | 25/04/21 | R 27 FK Spartak Moskova 1 CSKA Moskova 0 B16:30 | 01/05/21 | R 28 CSKA Moskova 1 FK Ufa 1 G19:30 | 08/05/21 | R 29 CSKA Moskova 3 FK Krasnodar 1 M14:00 | 16/05/21 | R 30 FK Dinamo Moscow 3 CSKA Moskova 2 |
| 7 | |  FK Dinamo Moscow | 30 | 15 | 5 | 10 | 44 | 33 | 11 | 50 | B16:30 | 11/04/21 | R 25 FK Dinamo Moscow 2 Ural Ekaterinburg 2 G16:30 | 17/04/21 | R 26 SK Rotor 0 FK Dinamo Moscow 3 M19:00 | 24/04/21 | R 27 FK Dinamo Moscow 0 FK Khimki 1 M14:00 | 01/05/21 | R 28 FK Rubin Kazan 2 FK Dinamo Moscow 0 B16:30 | 08/05/21 | R 29 FK Lokomotiv Moskova 0 FK Dinamo Moscow 0 G14:00 | 16/05/21 | R 30 FK Dinamo Moscow 3 CSKA Moskova 2 |
| 8 | |  FK Khimki | 30 | 13 | 6 | 11 | 35 | 39 | -4 | 45 | G14:00 | 10/04/21 | R 25 FK Khimki 1 FK Tambov 0 M14:00 | 17/04/21 | R 26 RFK Akhmat Grozny 3 FK Khimki 1 G19:00 | 24/04/21 | R 27 FK Dinamo Moscow 0 FK Khimki 1 G14:00 | 02/05/21 | R 28 FK Khimki 1 Ural Ekaterinburg 0 M19:00 | 10/05/21 | R 29 FK Spartak Moskova 2 FK Khimki 1 B14:00 | 16/05/21 | R 30 FK Khimki 0 FK Sochi 0 |
| 9 | |  FK Rostov | 30 | 13 | 4 | 13 | 37 | 35 | 2 | 43 | M19:00 | 10/04/21 | R 25 FK Rostov 0 FK Rubin Kazan 1 M16:30 | 17/04/21 | R 26 FK Lokomotiv Moskova 4 FK Rostov 1 G16:30 | 25/04/21 | R 27 FK Rostov 1 PFK Arsenal Tula 0 G16:30 | 02/05/21 | R 28 FK Rostov 2 FK Tambov 0 M16:30 | 10/05/21 | R 29 Ural Ekaterinburg 1 FK Rostov 0 M14:00 | 16/05/21 | R 30 FK Rostov 1 FK Krasnodar 3 |
| 10 | |  FK Krasnodar | 30 | 12 | 5 | 13 | 52 | 45 | 7 | 41 | M14:00 | 11/04/21 | R 25 PFK Arsenal Tula 1 FK Krasnodar 0 B19:00 | 17/04/21 | R 26 FK Krasnodar 2 FK Zenit St Petersburg 2 G19:00 | 25/04/21 | R 27 FK Rubin Kazan 0 FK Krasnodar 1 M19:00 | 01/05/21 | R 28 FK Krasnodar 1 FK Sochi 3 M19:30 | 08/05/21 | R 29 CSKA Moskova 3 FK Krasnodar 1 G14:00 | 16/05/21 | R 30 FK Rostov 1 FK Krasnodar 3 |
| 11 | |  RFK Akhmat Grozny | 30 | 11 | 7 | 12 | 36 | 38 | -2 | 40 | M16:30 | 10/04/21 | R 25 FK Ufa 3 RFK Akhmat Grozny 0 G14:00 | 17/04/21 | R 26 RFK Akhmat Grozny 3 FK Khimki 1 B14:00 | 24/04/21 | R 27 Ural Ekaterinburg 1 RFK Akhmat Grozny 1 M14:00 | 01/05/21 | R 28 SK Rotor 1 RFK Akhmat Grozny 0 G18:00 | 07/05/21 | R 29 RFK Akhmat Grozny 3 FK Tambov 1 B14:00 | 16/05/21 | R 30 RFK Akhmat Grozny 2 FK Spartak Moskova 2 |
| 12 | |  Ural Ekaterinburg | 30 | 7 | 13 | 10 | 26 | 36 | -10 | 34 | B16:30 | 11/04/21 | R 25 FK Dinamo Moscow 2 Ural Ekaterinburg 2 M12:00 | 18/04/21 | R 26 Ural Ekaterinburg 0 FK Rubin Kazan 1 B14:00 | 24/04/21 | R 27 Ural Ekaterinburg 1 RFK Akhmat Grozny 1 M14:00 | 02/05/21 | R 28 FK Khimki 1 Ural Ekaterinburg 0 G16:30 | 10/05/21 | R 29 Ural Ekaterinburg 1 FK Rostov 0 M14:00 | 16/05/21 | R 30 FK Lokomotiv Moskova 1 Ural Ekaterinburg 0 |
| 13 | |  FK Ufa | 30 | 6 | 7 | 17 | 26 | 46 | -20 | 25 | G16:30 | 10/04/21 | R 25 FK Ufa 3 RFK Akhmat Grozny 0 G19:00 | 18/04/21 | R 26 FK Spartak Moskova 0 FK Ufa 3 M14:00 | 25/04/21 | R 27 FK Ufa 2 FK Sochi 3 B16:30 | 01/05/21 | R 28 CSKA Moskova 1 FK Ufa 1 B14:00 | 08/05/21 | R 29 FK Ufa 0 FK Zenit St Petersburg 0 G16:00 | 16/05/21 | R 30 FK Ufa 2 PFK Arsenal Tula 1 |
| 14 | |  PFK Arsenal Tula | 30 | 6 | 5 | 19 | 28 | 51 | -23 | 23 | G14:00 | 11/04/21 | R 25 PFK Arsenal Tula 1 FK Krasnodar 0 G14:00 | 18/04/21 | R 26 PFK Arsenal Tula 4 FK Tambov 0 M16:30 | 25/04/21 | R 27 FK Rostov 1 PFK Arsenal Tula 0 M16:30 | 03/05/21 | R 28 PFK Arsenal Tula 1 FK Spartak Moskova 2 M16:30 | 08/05/21 | R 29 PFK Arsenal Tula 2 FK Rubin Kazan 4 M16:00 | 16/05/21 | R 30 FK Ufa 2 PFK Arsenal Tula 1 |
| 15 | |  SK Rotor | 30 | 5 | 7 | 18 | 15 | 52 | -37 | 22 | M19:00 | 12/04/21 | R 25 CSKA Moskova 2 SK Rotor 0 M16:30 | 17/04/21 | R 26 SK Rotor 0 FK Dinamo Moscow 3 M16:30 | 24/04/21 | R 27 FK Zenit St Petersburg 6 SK Rotor 0 G14:00 | 01/05/21 | R 28 SK Rotor 1 RFK Akhmat Grozny 0 M20:00 | 07/05/21 | R 29 FK Sochi 2 SK Rotor 1 B14:00 | 16/05/21 | R 30 FK Rubin Kazan 1 SK Rotor 1 |
| 16 | |  FK Tambov | 30 | 3 | 4 | 23 | 19 | 65 | -46 | 13 | M14:00 | 10/04/21 | R 25 FK Khimki 1 FK Tambov 0 M14:00 | 18/04/21 | R 26 PFK Arsenal Tula 4 FK Tambov 0 M19:00 | 24/04/21 | R 27 FK Tambov 2 FK Lokomotiv Moskova 5 M16:30 | 02/05/21 | R 28 FK Rostov 2 FK Tambov 0 M18:00 | 07/05/21 | R 29 RFK Akhmat Grozny 3 FK Tambov 1 M14:00 | 16/05/21 | R 30 FK Tambov 1 FK Zenit St Petersburg 5 |
