| 1 | |  FK Zenit St Petersburg | 30 | 19 | 8 | 3 | 66 | 28 | 38 | 65 | G16:30 | 16/04/22 | R 25  FK Zenit St Petersburg 3 Ural Ekaterinburg 1 G19:00 | 25/04/22 | R 26 FK Krasnodar 1 FK Zenit St Petersburg 3 G19:30 | 30/04/22 | R 27 FK Zenit St Petersburg 3 FK Lokomotiv Moskova 1 G16:30 | 07/05/22 | R 28 FK Zenit St Petersburg 1 FK Khimki 0 B16:30 | 15/05/22 | R 29 FK Spartak Moskova 1 FK Zenit St Petersburg 1 M17:00 | 21/05/22 | R 30 FC Pari Nizhny Novgorod 1 FK Zenit St Petersburg 0 |
| 2 | |  FK Sochi | 30 | 17 | 5 | 8 | 54 | 30 | 24 | 56 | B16:30 | 17/04/22 | R 25 FK Sochi 2 FK Lokomotiv Moskova 2 G19:00 | 23/04/22 | R 26 FK Sochi 3 RFK Akhmat Grozny 2 G14:00 | 30/04/22 | R 27 FK Rubin Kazan 0 FK Sochi 6 G19:00 | 07/05/22 | R 28 CSKA Moskova 0 FK Sochi 1 B19:00 | 13/05/22 | R 29 FK Sochi 0 FC Pari Nizhny Novgorod 0 G17:00 | 21/05/22 | R 30 FK Dinamo Moscow 1 FK Sochi 5 |
| 3 | |  FK Dinamo Moscow | 30 | 16 | 5 | 9 | 53 | 41 | 12 | 53 | G19:30 | 15/04/22 | R 25 FK Dinamo Moscow 2 RFK Akhmat Grozny 0 M19:30 | 24/04/22 | R 26 CSKA Moskova 1 FK Dinamo Moscow 0 M14:00 | 30/04/22 | R 27 FK Dinamo Moscow 2 Ural Ekaterinburg 3 M18:00 | 06/05/22 | R 28 PFK Krylia Sovyetov Samara 5 FK Dinamo Moscow 2 B16:30 | 14/05/22 | R 29 FK Lokomotiv Moskova 3 FK Dinamo Moscow 3 M17:00 | 21/05/22 | R 30 FK Dinamo Moscow 1 FK Sochi 5 |
| 4 | |  FK Krasnodar | 30 | 14 | 8 | 8 | 42 | 30 | 12 | 50 | M19:00 | 25/04/22 | R 26 FK Krasnodar 1 FK Zenit St Petersburg 3 G16:30 | 30/04/22 | R 27 FK Krasnodar 2 FK Rostov 1 G19:00 | 04/05/22 | R 19 FK Krasnodar 1 FK Lokomotiv Moskova 0 B16:30 | 08/05/22 | R 28 PFK Arsenal Tula 1 FK Krasnodar 1 G19:00 | 15/05/22 | R 29 FK Krasnodar 1 CSKA Moskova 0 B17:00 | 21/05/22 | R 30 FK Krasnodar 1 RFK Akhmat Grozny 1 |
| 5 | |  CSKA Moskova | 30 | 15 | 5 | 10 | 42 | 29 | 13 | 50 | B14:00 | 16/04/22 | R 25 FK Ufa 1 CSKA Moskova 1 G19:30 | 24/04/22 | R 26 CSKA Moskova 1 FK Dinamo Moscow 0 M19:00 | 01/05/22 | R 27 RFK Akhmat Grozny 2 CSKA Moskova 0 M19:00 | 07/05/22 | R 28 CSKA Moskova 0 FK Sochi 1 M19:00 | 15/05/22 | R 29 FK Krasnodar 1 CSKA Moskova 0 G17:00 | 21/05/22 | R 30 CSKA Moskova 4 FK Rostov 0 |
| 6 | |  FK Lokomotiv Moskova | 30 | 13 | 9 | 8 | 43 | 39 | 4 | 48 | G16:30 | 23/04/22 | R 26 FK Lokomotiv Moskova 2 FC Pari Nizhny Novgorod 1 M19:30 | 30/04/22 | R 27 FK Zenit St Petersburg 3 FK Lokomotiv Moskova 1 M19:00 | 04/05/22 | R 19 FK Krasnodar 1 FK Lokomotiv Moskova 0 G19:00 | 08/05/22 | R 28 FK Lokomotiv Moskova 1 FK Rubin Kazan 0 B16:30 | 14/05/22 | R 29 FK Lokomotiv Moskova 3 FK Dinamo Moscow 3 G17:00 | 21/05/22 | R 30 PFK Krylia Sovyetov Samara 0 FK Lokomotiv Moskova 1 |
| 7 | |  RFK Akhmat Grozny | 30 | 13 | 3 | 14 | 36 | 38 | -2 | 42 | M19:30 | 15/04/22 | R 25 FK Dinamo Moscow 2 RFK Akhmat Grozny 0 M19:00 | 23/04/22 | R 26 FK Sochi 3 RFK Akhmat Grozny 2 G19:00 | 01/05/22 | R 27 RFK Akhmat Grozny 2 CSKA Moskova 0 G16:30 | 07/05/22 | R 28 FC Pari Nizhny Novgorod 0 RFK Akhmat Grozny 1 G19:00 | 14/05/22 | R 29 RFK Akhmat Grozny 1 PFK Krylia Sovyetov Samara 0 B17:00 | 21/05/22 | R 30 FK Krasnodar 1 RFK Akhmat Grozny 1 |
| 8 | |  PFK Krylia Sovyetov Samara | 30 | 12 | 5 | 13 | 39 | 36 | 3 | 41 | G16:30 | 17/04/22 | R 25 PFK Krylia Sovyetov Samara 2 FK Krasnodar 0 M14:00 | 24/04/22 | R 26 FK Khimki 4 PFK Krylia Sovyetov Samara 1 M14:00 | 01/05/22 | R 27 FK Spartak Moskova 2 PFK Krylia Sovyetov Samara 1 G18:00 | 06/05/22 | R 28 PFK Krylia Sovyetov Samara 5 FK Dinamo Moscow 2 M19:00 | 14/05/22 | R 29 RFK Akhmat Grozny 1 PFK Krylia Sovyetov Samara 0 M17:00 | 21/05/22 | R 30 PFK Krylia Sovyetov Samara 0 FK Lokomotiv Moskova 1 |
| 9 | |  FK Rostov | 30 | 10 | 8 | 12 | 47 | 51 | -4 | 38 | G14:00 | 17/04/22 | R 25 PFK Arsenal Tula 1 FK Rostov 2 G16:30 | 24/04/22 | R 26 FK Rostov 3 FK Spartak Moskova 2 M16:30 | 30/04/22 | R 27 FK Krasnodar 2 FK Rostov 1 B14:00 | 08/05/22 | R 28 FK Ufa 0 FK Rostov 0 G16:30 | 14/05/22 | R 29 FK Rostov 2 FK Khimki 1 M17:00 | 21/05/22 | R 30 CSKA Moskova 4 FK Rostov 0 |
| 10 | |  FK Spartak Moskova | 30 | 10 | 8 | 12 | 37 | 41 | -4 | 38 | B19:00 | 16/04/22 | R 25 FK Spartak Moskova 1 FK Rubin Kazan 1 M16:30 | 24/04/22 | R 26 FK Rostov 3 FK Spartak Moskova 2 G14:00 | 01/05/22 | R 27 FK Spartak Moskova 2 PFK Krylia Sovyetov Samara 1 G14:00 | 07/05/22 | R 28 Ural Ekaterinburg 1 FK Spartak Moskova 3 B16:30 | 15/05/22 | R 29 FK Spartak Moskova 1 FK Zenit St Petersburg 1 M17:00 | 21/05/22 | R 30 FK Khimki 2 FK Spartak Moskova 1 |
| 11 | |  FC Pari Nizhny Novgorod | 30 | 8 | 9 | 13 | 26 | 39 | -13 | 33 | B19:00 | 17/04/22 | R 25 FC Pari Nizhny Novgorod 0 FK Khimki 0 M16:30 | 23/04/22 | R 26 FK Lokomotiv Moskova 2 FC Pari Nizhny Novgorod 1 B19:00 | 02/05/22 | R 27 PFK Arsenal Tula 2 FC Pari Nizhny Novgorod 2 M16:30 | 07/05/22 | R 28 FC Pari Nizhny Novgorod 0 RFK Akhmat Grozny 1 B19:00 | 13/05/22 | R 29 FK Sochi 0 FC Pari Nizhny Novgorod 0 G17:00 | 21/05/22 | R 30 FC Pari Nizhny Novgorod 1 FK Zenit St Petersburg 0 |
| 12 | |  Ural Ekaterinburg | 30 | 8 | 9 | 13 | 27 | 35 | -8 | 33 | M16:30 | 16/04/22 | R 25 FK Zenit St Petersburg 3 Ural Ekaterinburg 1 G14:00 | 23/04/22 | R 26 Ural Ekaterinburg 2 FK Ufa 1 G14:00 | 30/04/22 | R 27 FK Dinamo Moscow 2 Ural Ekaterinburg 3 M14:00 | 07/05/22 | R 28 Ural Ekaterinburg 1 FK Spartak Moskova 3 G14:00 | 15/05/22 | R 29 Ural Ekaterinburg 3 FK Rubin Kazan 0 G17:00 | 21/05/22 | R 30 PFK Arsenal Tula 1 Ural Ekaterinburg 2 |
| 13 | |  FK Khimki | 30 | 7 | 11 | 12 | 34 | 47 | -13 | 32 | B16:30 | 01/05/22 | R 27 FK Khimki 1 FK Ufa 1 M16:30 | 07/05/22 | R 28 FK Zenit St Petersburg 1 FK Khimki 0 M16:30 | 14/05/22 | R 29 FK Rostov 2 FK Khimki 1 G17:00 | 21/05/22 | R 30 FK Khimki 2 FK Spartak Moskova 1 M12:30 | 25/05/22 | R 1 FC SKA-Khabarovsk 1 FK Khimki 0 G14:00 | 28/05/22 | R 1 FK Khimki 3 FC SKA-Khabarovsk 0 |
| 14 | |  FK Ufa | 30 | 6 | 12 | 12 | 29 | 40 | -11 | 30 | B16:30 | 01/05/22 | R 27 FK Khimki 1 FK Ufa 1 B14:00 | 08/05/22 | R 28 FK Ufa 0 FK Rostov 0 G14:00 | 14/05/22 | R 29 FK Ufa 2 PFK Arsenal Tula 1 G17:00 | 21/05/22 | R 30 FK Rubin Kazan 1 FK Ufa 2 B17:30 | 25/05/22 | R 1 FC Orenburg 2 FK Ufa 2 M16:00 | 28/05/22 | R 1 FK Ufa 1 FC Orenburg 2 |
| 15 | |  FK Rubin Kazan | 30 | 8 | 5 | 17 | 34 | 56 | -22 | 29 | B19:00 | 16/04/22 | R 25 FK Spartak Moskova 1 FK Rubin Kazan 1 G14:00 | 24/04/22 | R 26 FK Rubin Kazan 1 PFK Arsenal Tula 0 M14:00 | 30/04/22 | R 27 FK Rubin Kazan 0 FK Sochi 6 M19:00 | 08/05/22 | R 28 FK Lokomotiv Moskova 1 FK Rubin Kazan 0 M14:00 | 15/05/22 | R 29 Ural Ekaterinburg 3 FK Rubin Kazan 0 M17:00 | 21/05/22 | R 30 FK Rubin Kazan 1 FK Ufa 2 |
| 16 | |  PFK Arsenal Tula | 30 | 5 | 8 | 17 | 30 | 59 | -29 | 23 | M14:00 | 17/04/22 | R 25 PFK Arsenal Tula 1 FK Rostov 2 M14:00 | 24/04/22 | R 26 FK Rubin Kazan 1 PFK Arsenal Tula 0 B19:00 | 02/05/22 | R 27 PFK Arsenal Tula 2 FC Pari Nizhny Novgorod 2 B16:30 | 08/05/22 | R 28 PFK Arsenal Tula 1 FK Krasnodar 1 M14:00 | 14/05/22 | R 29 FK Ufa 2 PFK Arsenal Tula 1 M17:00 | 21/05/22 | R 30 PFK Arsenal Tula 1 Ural Ekaterinburg 2 |
