| 1 | |  Libertad Asuncion | 22 | 18 | 3 | 1 | 49 | 14 | 35 | 57 | G02:15 | 23/05/22 | R 17  Libertad Asuncion 1 Nacional Asuncion 0 B02:15 | 14/06/22 | R 18 Club Guarani 1 Libertad Asuncion 1 G02:15 | 18/06/22 | R 19 Libertad Asuncion 2 Guairena FC 0 G01:30 | 22/06/22 | R 20 Sol De America 0 Libertad Asuncion 3 G02:15 | 26/06/22 | R 21 Libertad Asuncion 1 Cerro Porteno 0 G02:15 | 03/07/22 | R 22 Resistencia FC 0 Libertad Asuncion 4 |
| 2 | |  Cerro Porteno | 22 | 16 | 2 | 4 | 38 | 13 | 25 | 50 | G23:30 | 22/05/22 | R 17 Club Olimpia 0 Cerro Porteno 4 G02:15 | 15/06/22 | R 18 Cerro Porteno 1 Resistencia FC 0 G23:30 | 18/06/22 | R 19 12 De Octubre De Itaugua 0 Cerro Porteno 1 G01:30 | 22/06/22 | R 20 Cerro Porteno 3 Club General Caballero JLM 1 M02:15 | 26/06/22 | R 21 Libertad Asuncion 1 Cerro Porteno 0 G00:00 | 03/07/22 | R 22 Cerro Porteno 1 Tacuary Asuncion 0 |
| 3 | |  Club Olimpia | 22 | 13 | 4 | 5 | 41 | 23 | 18 | 43 | M23:30 | 22/05/22 | R 17 Club Olimpia 0 Cerro Porteno 4 G00:00 | 15/06/22 | R 18 Sportivo Ameliano 1 Club Olimpia 4 G23:30 | 19/06/22 | R 19 Club Olimpia 6 Resistencia FC 1 B02:15 | 23/06/22 | R 20 Nacional Asuncion 1 Club Olimpia 1 G23:30 | 26/06/22 | R 21 Club Olimpia 4 12 De Octubre De Itaugua 1 G01:15 | 04/07/22 | R 22 Club Guarani 0 Club Olimpia 2 |
| 4 | |  Club Guarani | 22 | 9 | 5 | 8 | 30 | 24 | 6 | 32 | G02:00 | 22/05/22 | R 17 Club General Caballero JLM 0 Club Guarani 4 B02:15 | 14/06/22 | R 18 Club Guarani 1 Libertad Asuncion 1 G01:45 | 20/06/22 | R 19 Tacuary Asuncion 0 Club Guarani 2 B00:00 | 24/06/22 | R 20 Club Guarani 1 Sportivo Ameliano 1 G01:45 | 27/06/22 | R 21 Nacional Asuncion 0 Club Guarani 1 M01:15 | 04/07/22 | R 22 Club Guarani 0 Club Olimpia 2 |
| 5 | |  Resistencia FC | 22 | 7 | 7 | 8 | 30 | 36 | -6 | 28 | B23:30 | 21/05/22 | R 17 Resistencia FC 0 Sol De America 0 M02:15 | 15/06/22 | R 18 Cerro Porteno 1 Resistencia FC 0 M23:30 | 19/06/22 | R 19 Club Olimpia 6 Resistencia FC 1 M00:00 | 23/06/22 | R 20 Resistencia FC 0 12 De Octubre De Itaugua 1 M00:00 | 26/06/22 | R 21 Club General Caballero JLM 2 Resistencia FC 1 M02:15 | 03/07/22 | R 22 Resistencia FC 0 Libertad Asuncion 4 |
| 6 | |  Nacional Asuncion | 22 | 7 | 5 | 10 | 27 | 32 | -5 | 26 | M02:15 | 23/05/22 | R 17 Libertad Asuncion 1 Nacional Asuncion 0 G00:00 | 14/06/22 | R 18 Nacional Asuncion 3 Tacuary Asuncion 0 B01:45 | 19/06/22 | R 19 Sportivo Ameliano 2 Nacional Asuncion 2 B02:15 | 23/06/22 | R 20 Nacional Asuncion 1 Club Olimpia 1 M01:45 | 27/06/22 | R 21 Nacional Asuncion 0 Club Guarani 1 B00:00 | 02/07/22 | R 22 Guairena FC 1 Nacional Asuncion 1 |
| 7 | |  Sol De America | 22 | 6 | 7 | 9 | 20 | 28 | -8 | 25 | B23:30 | 21/05/22 | R 17 Resistencia FC 0 Sol De America 0 B01:45 | 13/06/22 | R 18 Sol De America 0 12 De Octubre De Itaugua 0 B00:00 | 18/06/22 | R 19 Club General Caballero JLM 1 Sol De America 1 M01:30 | 22/06/22 | R 20 Sol De America 0 Libertad Asuncion 3 B02:15 | 28/06/22 | R 21 Tacuary Asuncion 2 Sol De America 2 M02:15 | 02/07/22 | R 22 Sol De America 0 Sportivo Ameliano 1 |
| 8 | |  Guairena FC | 22 | 5 | 8 | 9 | 21 | 26 | -5 | 23 | G00:00 | 31/05/22 | R 17 12 De Octubre De Itaugua 0 Guairena FC 4 M23:30 | 12/06/22 | R 18 Guairena FC 1 Club General Caballero JLM 2 M02:15 | 18/06/22 | R 19 Libertad Asuncion 2 Guairena FC 0 B02:15 | 24/06/22 | R 20 Guairena FC 0 Tacuary Asuncion 0 B00:00 | 28/06/22 | R 21 Sportivo Ameliano 2 Guairena FC 2 B00:00 | 02/07/22 | R 22 Guairena FC 1 Nacional Asuncion 1 |
| 9 | |  Club General Caballero JLM | 22 | 6 | 5 | 11 | 23 | 33 | -10 | 23 | M02:00 | 22/05/22 | R 17 Club General Caballero JLM 0 Club Guarani 4 G23:30 | 12/06/22 | R 18 Guairena FC 1 Club General Caballero JLM 2 B00:00 | 18/06/22 | R 19 Club General Caballero JLM 1 Sol De America 1 M01:30 | 22/06/22 | R 20 Cerro Porteno 3 Club General Caballero JLM 1 G00:00 | 26/06/22 | R 21 Club General Caballero JLM 2 Resistencia FC 1 G23:00 | 03/07/22 | R 22 12 De Octubre De Itaugua 1 Club General Caballero JLM 3 |
| 10 | |  Tacuary Asuncion | 22 | 6 | 4 | 12 | 16 | 29 | -13 | 22 | G00:30 | 21/05/22 | R 17 Tacuary Asuncion 1 Sportivo Ameliano 0 M00:00 | 14/06/22 | R 18 Nacional Asuncion 3 Tacuary Asuncion 0 M01:45 | 20/06/22 | R 19 Tacuary Asuncion 0 Club Guarani 2 B02:15 | 24/06/22 | R 20 Guairena FC 0 Tacuary Asuncion 0 B02:15 | 28/06/22 | R 21 Tacuary Asuncion 2 Sol De America 2 M00:00 | 03/07/22 | R 22 Cerro Porteno 1 Tacuary Asuncion 0 |
| 11 | |  Sportivo Ameliano | 22 | 5 | 4 | 13 | 25 | 38 | -13 | 19 | M00:30 | 21/05/22 | R 17 Tacuary Asuncion 1 Sportivo Ameliano 0 M00:00 | 15/06/22 | R 18 Sportivo Ameliano 1 Club Olimpia 4 B01:45 | 19/06/22 | R 19 Sportivo Ameliano 2 Nacional Asuncion 2 B00:00 | 24/06/22 | R 20 Club Guarani 1 Sportivo Ameliano 1 B00:00 | 28/06/22 | R 21 Sportivo Ameliano 2 Guairena FC 2 G02:15 | 02/07/22 | R 22 Sol De America 0 Sportivo Ameliano 1 |
| 12 | |  12 De Octubre De Itaugua | 22 | 3 | 8 | 11 | 16 | 40 | -24 | 17 | M00:00 | 31/05/22 | R 17 12 De Octubre De Itaugua 0 Guairena FC 4 B01:45 | 13/06/22 | R 18 Sol De America 0 12 De Octubre De Itaugua 0 M23:30 | 18/06/22 | R 19 12 De Octubre De Itaugua 0 Cerro Porteno 1 G00:00 | 23/06/22 | R 20 Resistencia FC 0 12 De Octubre De Itaugua 1 M23:30 | 26/06/22 | R 21 Club Olimpia 4 12 De Octubre De Itaugua 1 M23:00 | 03/07/22 | R 22 12 De Octubre De Itaugua 1 Club General Caballero JLM 3 |
