| 1 | |  Rot Weiss Essen | 38 | 26 | 9 | 3 | 84 | 32 | 52 | 87 | B16:30 | 16/04/22 | R 34  Rot Weiss Essen 1 Borussia Monchengladbach II 1 G20:30 | 19/04/22 | R 28 Rot Weiss Essen 4 Lippstadt 08 0 G20:30 | 22/04/22 | R 35 VfL Sportfreunde Lotte 1929 0 Rot Weiss Essen 3 G20:30 | 29/04/22 | R 36 Rot Weiss Essen 3 Wegberg Beeck 1 G15:00 | 07/05/22 | R 37 SV Rodinghausen 0 Rot Weiss Essen 3 G15:00 | 14/05/22 | R 38 Rot Weiss Essen 2 Rot Weiss Ahlen 0 |
| 2 | |  SC Preussen 06 Munster | 38 | 26 | 9 | 3 | 73 | 24 | 49 | 87 | B15:00 | 16/04/22 | R 34 Lippstadt 08 3 SC Preussen 06 Munster 3 G20:00 | 19/04/22 | R 29 SC Preussen 06 Munster 1 Fortuna Cologne 0 G15:00 | 24/04/22 | R 35 RW Oberhausen 0 SC Preussen 06 Munster 3 G20:30 | 29/04/22 | R 36 SC Preussen 06 Munster 3 Krefelder FC Uerdingen 05 0 B20:30 | 06/05/22 | R 37 SC Wiedenbruck 0 SC Preussen 06 Munster 0 G15:00 | 14/05/22 | R 38 SC Preussen 06 Munster 2 1. FC Cologne II 1 |
| 3 | |  Wuppertaler | 38 | 23 | 9 | 6 | 68 | 28 | 40 | 78 | G16:30 | 16/04/22 | R 34 Wuppertaler 2 1. FC Cologne II 0 G20:00 | 20/04/22 | R 32 Wuppertaler 2 Krefelder FC Uerdingen 05 0 G15:00 | 24/04/22 | R 35 Alemannia Aachen 1 Wuppertaler 2 G15:00 | 30/04/22 | R 36 Wuppertaler 1 Borussia Monchengladbach II 0 M15:00 | 08/05/22 | R 37 VfL Sportfreunde Lotte 1929 2 Wuppertaler 1 G15:00 | 14/05/22 | R 38 Wuppertaler 4 Wegberg Beeck 1 |
| 4 | |  RW Oberhausen | 38 | 22 | 9 | 7 | 68 | 35 | 33 | 75 | G20:30 | 08/04/22 | R 33 RW Oberhausen 2 Fortuna Dusseldorf II 1 G15:00 | 16/04/22 | R 34 Homberg 0 RW Oberhausen 1 M15:00 | 24/04/22 | R 35 RW Oberhausen 0 SC Preussen 06 Munster 3 G20:30 | 29/04/22 | R 36 FC Schalke 04 II 0 RW Oberhausen 1 M15:00 | 07/05/22 | R 37 RW Oberhausen 0 Lippstadt 08 1 G15:00 | 14/05/22 | R 38 Bonner 1 RW Oberhausen 5 |
| 5 | |  Fortuna Cologne | 38 | 20 | 14 | 4 | 62 | 31 | 31 | 74 | M15:00 | 16/04/22 | R 34 Fortuna Cologne 2 SC Wiedenbruck 3 M20:00 | 19/04/22 | R 29 SC Preussen 06 Munster 1 Fortuna Cologne 0 B15:00 | 23/04/22 | R 35 1. FC Cologne II 2 Fortuna Cologne 2 B15:00 | 30/04/22 | R 36 Fortuna Cologne 0 Alemannia Aachen 0 G15:00 | 07/05/22 | R 37 Borussia Monchengladbach II 0 Fortuna Cologne 4 G15:00 | 14/05/22 | R 38 Fortuna Cologne 2 VfL Sportfreunde Lotte 1929 1 |
| 6 | |  SV Rodinghausen | 38 | 19 | 7 | 12 | 45 | 35 | 10 | 64 | B19:30 | 13/04/22 | R 32 SV Rodinghausen 0 Borussia Monchengladbach II 0 B15:00 | 16/04/22 | R 34 SV Rodinghausen 1 Wegberg Beeck 1 G15:00 | 23/04/22 | R 35 Bonner 0 SV Rodinghausen 1 M15:00 | 30/04/22 | R 36 Rot Weiss Ahlen 2 SV Rodinghausen 1 M15:00 | 07/05/22 | R 37 SV Rodinghausen 0 Rot Weiss Essen 3 G15:00 | 14/05/22 | R 38 19 Straelen 1 SV Rodinghausen 4 |
| 7 | |  1. FC Cologne II | 38 | 17 | 11 | 10 | 70 | 49 | 21 | 62 | M16:30 | 16/04/22 | R 34 Wuppertaler 2 1. FC Cologne II 0 B20:30 | 20/04/22 | R 26 Alemannia Aachen 1 1. FC Cologne II 1 B15:00 | 23/04/22 | R 35 1. FC Cologne II 2 Fortuna Cologne 2 G15:00 | 29/04/22 | R 36 Fortuna Dusseldorf II 0 1. FC Cologne II 1 G13:00 | 07/05/22 | R 37 1. FC Cologne II 2 Homberg 1 M15:00 | 14/05/22 | R 38 SC Preussen 06 Munster 2 1. FC Cologne II 1 |
| 8 | |  SC Wiedenbruck | 38 | 14 | 13 | 11 | 48 | 37 | 11 | 55 | M15:00 | 09/04/22 | R 33 SC Wiedenbruck 0 Wuppertaler 1 G15:00 | 16/04/22 | R 34 Fortuna Cologne 2 SC Wiedenbruck 3 G15:00 | 23/04/22 | R 35 SC Wiedenbruck 3 Fortuna Dusseldorf II 1 M15:00 | 30/04/22 | R 36 Homberg 2 SC Wiedenbruck 1 B20:30 | 06/05/22 | R 37 SC Wiedenbruck 0 SC Preussen 06 Munster 0 M20:00 | 13/05/22 | R 38 FC Schalke 04 II 5 SC Wiedenbruck 1 |
| 9 | |  FC Schalke 04 II | 38 | 13 | 8 | 17 | 58 | 65 | -7 | 47 | M20:30 | 13/04/22 | R 26 Rot Weiss Ahlen 3 FC Schalke 04 II 2 G15:00 | 16/04/22 | R 34 FC Schalke 04 II 1 Bonner 0 G15:00 | 23/04/22 | R 35 Lippstadt 08 0 FC Schalke 04 II 1 M20:30 | 29/04/22 | R 36 FC Schalke 04 II 0 RW Oberhausen 1 G19:00 | 07/05/22 | R 37 Krefelder FC Uerdingen 05 3 FC Schalke 04 II 4 G20:00 | 13/05/22 | R 38 FC Schalke 04 II 5 SC Wiedenbruck 1 |
| 10 | |  Rot Weiss Ahlen | 38 | 11 | 14 | 13 | 50 | 67 | -17 | 47 | B15:00 | 16/04/22 | R 34 Rot Weiss Ahlen 1 VfL Sportfreunde Lotte 1929 1 G15:00 | 23/04/22 | R 35 Wegberg Beeck 0 Rot Weiss Ahlen 1 M20:30 | 27/04/22 | R 32 Rot Weiss Ahlen 0 Alemannia Aachen 2 G15:00 | 30/04/22 | R 36 Rot Weiss Ahlen 2 SV Rodinghausen 1 B15:00 | 07/05/22 | R 37 Rot Weiss Ahlen 1 Bonner 1 M15:00 | 14/05/22 | R 38 Rot Weiss Essen 2 Rot Weiss Ahlen 0 |
| 11 | |  Fortuna Dusseldorf II | 38 | 12 | 10 | 16 | 59 | 62 | -3 | 46 | G19:00 | 13/04/22 | R 26 Wuppertaler 0 Fortuna Dusseldorf II 2 G15:00 | 16/04/22 | R 34 Fortuna Dusseldorf II 1 Krefelder FC Uerdingen 05 0 M15:00 | 23/04/22 | R 35 SC Wiedenbruck 3 Fortuna Dusseldorf II 1 M15:00 | 29/04/22 | R 36 Fortuna Dusseldorf II 0 1. FC Cologne II 1 M20:30 | 06/05/22 | R 37 Alemannia Aachen 3 Fortuna Dusseldorf II 1 B15:00 | 14/05/22 | R 38 Fortuna Dusseldorf II 0 Borussia Monchengladbach II 0 |
| 12 | |  Alemannia Aachen | 38 | 11 | 11 | 16 | 43 | 51 | -8 | 44 | B20:30 | 20/04/22 | R 26 Alemannia Aachen 1 1. FC Cologne II 1 M15:00 | 24/04/22 | R 35 Alemannia Aachen 1 Wuppertaler 2 G20:30 | 27/04/22 | R 32 Rot Weiss Ahlen 0 Alemannia Aachen 2 B15:00 | 30/04/22 | R 36 Fortuna Cologne 0 Alemannia Aachen 0 G20:30 | 06/05/22 | R 37 Alemannia Aachen 3 Fortuna Dusseldorf II 1 B15:00 | 14/05/22 | R 38 Homberg 0 Alemannia Aachen 0 |
| 13 | |  Borussia Monchengladbach II | 38 | 12 | 7 | 19 | 42 | 51 | -9 | 43 | B19:30 | 13/04/22 | R 32 SV Rodinghausen 0 Borussia Monchengladbach II 0 B16:30 | 16/04/22 | R 34 Rot Weiss Essen 1 Borussia Monchengladbach II 1 G15:00 | 23/04/22 | R 35 Borussia Monchengladbach II 2 19 Straelen 1 M15:00 | 30/04/22 | R 36 Wuppertaler 1 Borussia Monchengladbach II 0 M15:00 | 07/05/22 | R 37 Borussia Monchengladbach II 0 Fortuna Cologne 4 B15:00 | 14/05/22 | R 38 Fortuna Dusseldorf II 0 Borussia Monchengladbach II 0 |
| 14 | |  Lippstadt 08 | 38 | 12 | 7 | 19 | 54 | 65 | -11 | 43 | M20:30 | 19/04/22 | R 28 Rot Weiss Essen 4 Lippstadt 08 0 M15:00 | 23/04/22 | R 35 Lippstadt 08 0 FC Schalke 04 II 1 M19:00 | 27/04/22 | R 33 Lippstadt 08 0 Homberg 1 B15:00 | 30/04/22 | R 36 Lippstadt 08 1 Bonner 1 G15:00 | 07/05/22 | R 37 RW Oberhausen 0 Lippstadt 08 1 M15:00 | 14/05/22 | R 38 Lippstadt 08 3 Krefelder FC Uerdingen 05 4 |
| 15 | |  19 Straelen | 38 | 12 | 7 | 19 | 42 | 64 | -22 | 43 | B15:00 | 09/04/22 | R 33 1. FC Cologne II 0 19 Straelen 0 M15:00 | 16/04/22 | R 34 19 Straelen 0 Alemannia Aachen 1 M15:00 | 23/04/22 | R 35 Borussia Monchengladbach II 2 19 Straelen 1 G15:00 | 30/04/22 | R 36 19 Straelen 2 VfL Sportfreunde Lotte 1929 1 G15:00 | 07/05/22 | R 37 Wegberg Beeck 2 19 Straelen 3 M15:00 | 14/05/22 | R 38 19 Straelen 1 SV Rodinghausen 4 |
| 16 | |  Bonner | 38 | 10 | 9 | 19 | 44 | 63 | -19 | 39 | G15:00 | 09/04/22 | R 33 Bonner 2 Wegberg Beeck 0 M15:00 | 16/04/22 | R 34 FC Schalke 04 II 1 Bonner 0 M15:00 | 23/04/22 | R 35 Bonner 0 SV Rodinghausen 1 B15:00 | 30/04/22 | R 36 Lippstadt 08 1 Bonner 1 B15:00 | 07/05/22 | R 37 Rot Weiss Ahlen 1 Bonner 1 M15:00 | 14/05/22 | R 38 Bonner 1 RW Oberhausen 5 |
| 17 | |  Wegberg Beeck | 38 | 7 | 10 | 21 | 31 | 64 | -33 | 31 | M15:00 | 09/04/22 | R 33 Bonner 2 Wegberg Beeck 0 B15:00 | 16/04/22 | R 34 SV Rodinghausen 1 Wegberg Beeck 1 M15:00 | 23/04/22 | R 35 Wegberg Beeck 0 Rot Weiss Ahlen 1 M20:30 | 29/04/22 | R 36 Rot Weiss Essen 3 Wegberg Beeck 1 M15:00 | 07/05/22 | R 37 Wegberg Beeck 2 19 Straelen 3 M15:00 | 14/05/22 | R 38 Wuppertaler 4 Wegberg Beeck 1 |
| 18 | |  VfL Sportfreunde Lotte 1929 | 38 | 9 | 3 | 26 | 36 | 63 | -27 | 30 | M15:00 | 09/04/22 | R 33 VfL Sportfreunde Lotte 1929 0 SV Rodinghausen 1 B15:00 | 16/04/22 | R 34 Rot Weiss Ahlen 1 VfL Sportfreunde Lotte 1929 1 M20:30 | 22/04/22 | R 35 VfL Sportfreunde Lotte 1929 0 Rot Weiss Essen 3 M15:00 | 30/04/22 | R 36 19 Straelen 2 VfL Sportfreunde Lotte 1929 1 G15:00 | 08/05/22 | R 37 VfL Sportfreunde Lotte 1929 2 Wuppertaler 1 M15:00 | 14/05/22 | R 38 Fortuna Cologne 2 VfL Sportfreunde Lotte 1929 1 |
| 19 | |  Krefelder FC Uerdingen 05 | 38 | 6 | 9 | 23 | 39 | 96 | -57 | 27 | M15:00 | 16/04/22 | R 34 Fortuna Dusseldorf II 1 Krefelder FC Uerdingen 05 0 M20:00 | 20/04/22 | R 32 Wuppertaler 2 Krefelder FC Uerdingen 05 0 M15:00 | 23/04/22 | R 35 Krefelder FC Uerdingen 05 0 Homberg 4 M20:30 | 29/04/22 | R 36 SC Preussen 06 Munster 3 Krefelder FC Uerdingen 05 0 M19:00 | 07/05/22 | R 37 Krefelder FC Uerdingen 05 3 FC Schalke 04 II 4 G15:00 | 14/05/22 | R 38 Lippstadt 08 3 Krefelder FC Uerdingen 05 4 |
| 20 | |  Homberg | 38 | 6 | 8 | 24 | 30 | 64 | -34 | 26 | M15:00 | 16/04/22 | R 34 Homberg 0 RW Oberhausen 1 G15:00 | 23/04/22 | R 35 Krefelder FC Uerdingen 05 0 Homberg 4 G19:00 | 27/04/22 | R 33 Lippstadt 08 0 Homberg 1 G15:00 | 30/04/22 | R 36 Homberg 2 SC Wiedenbruck 1 M13:00 | 07/05/22 | R 37 1. FC Cologne II 2 Homberg 1 B15:00 | 14/05/22 | R 38 Homberg 0 Alemannia Aachen 0 |
