| 1 | |  Alebrijes de Oaxaca FC | 16 | 9 | 4 | 3 | 21 | 13 | 8 | 34 | G04:00 | 27/03/22 | R 14  Alebrijes de Oaxaca FC 5 CSD Dorados Sinaloa 1 M02:00 | 30/03/22 | R 15 Atlante FC 1 Alebrijes de Oaxaca FC 0 B01:00 | 06/04/22 | R 16 Alebrijes de Oaxaca FC 0 Pumas de Tabasco 0 G03:05 | 13/04/22 | R 17 CF Correcaminos UAT 0 Alebrijes de Oaxaca FC 1 M05:05 | 27/04/22 | R quarterfinal Cimarrones de Sonora FC 1 Alebrijes de Oaxaca FC 0 B01:00 | 01/05/22 | R quarterfinal Alebrijes de Oaxaca FC 0 Cimarrones de Sonora FC 0 |
| 2 | |  Leones Negros UDEG | 16 | 8 | 5 | 3 | 21 | 16 | 5 | 33 | G21:00 | 27/03/22 | R 14 Atletico Morelia 0 Leones Negros UDEG 1 B03:00 | 02/04/22 | R 15 Leones Negros UDEG 1 Tampico Madero FC 1 B00:00 | 11/04/22 | R 16 CD Tapatio 1 Leones Negros UDEG 1 G01:00 | 14/04/22 | R 17 Leones Negros UDEG 1 Cancun FC 0 M03:00 | 29/04/22 | R quarterfinal Atlante FC 2 Leones Negros UDEG 0 M00:00 | 02/05/22 | R quarterfinal Leones Negros UDEG 1 Atlante FC 2 |
| 3 | |  Club Celaya FC | 16 | 7 | 6 | 3 | 23 | 15 | 8 | 30 | B03:05 | 07/04/22 | R 16 Tampico Madero FC 2 Club Celaya FC 2 G05:05 | 14/04/22 | R 17 Club Celaya FC 1 Venados FC 0 G05:05 | 29/04/22 | R quarterfinal Cancun FC 0 Club Celaya FC 1 G02:05 | 02/05/22 | R quarterfinal Club Celaya FC 2 Cancun FC 1 M05:00 | 06/05/22 | R semifinal Cimarrones de Sonora FC 1 Club Celaya FC 0 B00:00 | 09/05/22 | R semifinal Club Celaya FC 1 Cimarrones de Sonora FC 1 |
| 4 | |  Atletico Morelia | 16 | 7 | 4 | 5 | 24 | 19 | 5 | 27 | B05:00 | 05/05/22 | R semifinal Atlante FC 0 Atletico Morelia 0 G01:00 | 08/05/22 | R semifinal Atletico Morelia 1 Atlante FC 0 B05:00 | 12/05/22 | R final Cimarrones de Sonora FC 0 Atletico Morelia 0 G01:00 | 15/05/22 | R final Atletico Morelia 2 Cimarrones de Sonora FC 0 G03:00 | 19/05/22 | R final Atlante FC 0 Atletico Morelia 1 M00:00 | 23/05/22 | R final Atletico Morelia (4) 0 Atlante FC (5) 1 |
| 5 | |  CD Mineros de Zacatecas | 16 | 7 | 3 | 6 | 23 | 18 | 5 | 27 | M02:00 | 31/03/22 | R 15 Club Celaya FC 2 CD Mineros de Zacatecas 1 B01:00 | 07/04/22 | R 16 CD Mineros de Zacatecas 1 Cimarrones de Sonora FC 1 M03:00 | 15/04/22 | R 17 Atlante FC 2 CD Mineros de Zacatecas 1 G01:00 | 21/04/22 | R 1 CD Mineros de Zacatecas 2 Tlaxcala FC 0 B03:00 | 27/04/22 | R quarterfinal CD Mineros de Zacatecas 3 Atletico Morelia 3 B01:00 | 30/04/22 | R quarterfinal Atletico Morelia 2 CD Mineros de Zacatecas 2 |
| 6 | |  Cancun FC | 16 | 7 | 2 | 7 | 15 | 17 | -2 | 26 | G06:05 | 30/03/22 | R 15 Cimarrones de Sonora FC 0 Cancun FC 1 G05:05 | 07/04/22 | R 16 Cancun FC 1 Tlaxcala FC 0 M01:00 | 14/04/22 | R 17 Leones Negros UDEG 1 Cancun FC 0 G03:10 | 22/04/22 | R 1 Cancun FC (4) 2 Tepatitlan FC (1) 2 M05:05 | 29/04/22 | R quarterfinal Cancun FC 0 Club Celaya FC 1 M02:05 | 02/05/22 | R quarterfinal Club Celaya FC 2 Cancun FC 1 |
| 7 | |  Atlante FC | 16 | 6 | 5 | 5 | 15 | 15 | 0 | 25 | G03:00 | 29/04/22 | R quarterfinal Atlante FC 2 Leones Negros UDEG 0 G00:00 | 02/05/22 | R quarterfinal Leones Negros UDEG 1 Atlante FC 2 B05:00 | 05/05/22 | R semifinal Atlante FC 0 Atletico Morelia 0 M01:00 | 08/05/22 | R semifinal Atletico Morelia 1 Atlante FC 0 M03:00 | 19/05/22 | R final Atlante FC 0 Atletico Morelia 1 G00:00 | 23/05/22 | R final Atletico Morelia (4) 0 Atlante FC (5) 1 |
| 8 | |  Cimarrones de Sonora FC | 16 | 6 | 5 | 5 | 20 | 14 | 6 | 24 | G05:05 | 27/04/22 | R quarterfinal Cimarrones de Sonora FC 1 Alebrijes de Oaxaca FC 0 B01:00 | 01/05/22 | R quarterfinal Alebrijes de Oaxaca FC 0 Cimarrones de Sonora FC 0 G05:00 | 06/05/22 | R semifinal Cimarrones de Sonora FC 1 Club Celaya FC 0 B00:00 | 09/05/22 | R semifinal Club Celaya FC 1 Cimarrones de Sonora FC 1 B05:00 | 12/05/22 | R final Cimarrones de Sonora FC 0 Atletico Morelia 0 M01:00 | 15/05/22 | R final Atletico Morelia 2 Cimarrones de Sonora FC 0 |
| 9 | |  CD Tapatio | 16 | 6 | 4 | 6 | 14 | 16 | -2 | 24 | M04:00 | 16/03/22 | R 12 Cancun FC 1 CD Tapatio 0 M02:00 | 23/03/22 | R 13 CD Tapatio 0 Alebrijes de Oaxaca FC 1 M06:00 | 26/03/22 | R 14 Club Celaya FC 5 CD Tapatio 0 B00:00 | 11/04/22 | R 16 CD Tapatio 1 Leones Negros UDEG 1 M01:00 | 16/04/22 | R 17 CD Tapatio 1 Raya2 Expansion 2 M05:10 | 22/04/22 | R 1 Cimarrones de Sonora FC 2 CD Tapatio 1 |
| 10 | |  Venados FC | 16 | 5 | 7 | 4 | 17 | 16 | 1 | 23 | B04:05 | 24/03/22 | R 13 Venados FC 0 Tepatitlan FC 0 B06:00 | 27/03/22 | R 14 Cimarrones de Sonora FC 1 Venados FC 1 G04:05 | 30/03/22 | R 15 Venados FC 2 CSD Dorados Sinaloa 1 B01:00 | 08/04/22 | R 16 Atletico Morelia 2 Venados FC 2 M05:05 | 14/04/22 | R 17 Club Celaya FC 1 Venados FC 0 M01:00 | 22/04/22 | R 1 Atlante FC 1 Venados FC 0 |
| 11 | |  Tepatitlan FC | 16 | 6 | 4 | 6 | 17 | 17 | 0 | 23 | B04:05 | 24/03/22 | R 13 Venados FC 0 Tepatitlan FC 0 G06:05 | 27/03/22 | R 14 Tepatitlan FC 2 Atlante FC 1 G03:00 | 01/04/22 | R 15 Tepatitlan FC 2 Atletico Morelia 1 G05:05 | 08/04/22 | R 16 Raya2 Expansion 0 Tepatitlan FC 2 M05:05 | 13/04/22 | R 17 Cimarrones de Sonora FC 2 Tepatitlan FC 0 M03:10 | 22/04/22 | R 1 Cancun FC (4) 2 Tepatitlan FC (1) 2 |
| 12 | |  Tlaxcala FC | 16 | 6 | 4 | 6 | 18 | 19 | -1 | 23 | G02:00 | 25/03/22 | R 13 Tlaxcala FC 4 CF Correcaminos UAT 0 G04:00 | 28/03/22 | R 14 CD Mineros de Zacatecas 3 Tlaxcala FC 4 G06:05 | 31/03/22 | R 15 Tlaxcala FC 2 Raya2 Expansion 1 M05:05 | 07/04/22 | R 16 Cancun FC 1 Tlaxcala FC 0 G01:00 | 13/04/22 | R 17 Tlaxcala FC 1 Tampico Madero FC 0 M01:00 | 21/04/22 | R 1 CD Mineros de Zacatecas 2 Tlaxcala FC 0 |
| 13 | |  CSD Dorados Sinaloa | 16 | 6 | 1 | 9 | 16 | 24 | -8 | 22 | M06:05 | 10/03/22 | R 11 CSD Dorados Sinaloa 0 CD Mineros de Zacatecas 1 M06:05 | 23/03/22 | R 13 CSD Dorados Sinaloa 0 Club Celaya FC 2 M04:00 | 27/03/22 | R 14 Alebrijes de Oaxaca FC 5 CSD Dorados Sinaloa 1 M04:05 | 30/03/22 | R 15 Venados FC 2 CSD Dorados Sinaloa 1 G05:05 | 06/04/22 | R 16 CSD Dorados Sinaloa 2 Atlante FC 1 G18:00 | 10/04/22 | R 12 Raya2 Expansion 0 CSD Dorados Sinaloa 1 |
| 14 | |  CF Correcaminos UAT | 16 | 4 | 6 | 6 | 18 | 21 | -3 | 19 | M04:00 | 11/03/22 | R 11 CD Tapatio 1 CF Correcaminos UAT 0 G04:05 | 17/03/22 | R 12 CF Correcaminos UAT 2 Atlante FC 0 M02:00 | 25/03/22 | R 13 Tlaxcala FC 4 CF Correcaminos UAT 0 G06:00 | 28/03/22 | R 14 CF Correcaminos UAT 2 Tampico Madero FC 1 G04:05 | 31/03/22 | R 15 Pumas de Tabasco 1 CF Correcaminos UAT 2 M03:05 | 13/04/22 | R 17 CF Correcaminos UAT 0 Alebrijes de Oaxaca FC 1 |
| 15 | |  Raya2 Expansion | 16 | 4 | 5 | 7 | 14 | 17 | -3 | 18 | B04:05 | 09/03/22 | R 11 Tampico Madero FC 0 Raya2 Expansion 0 B02:00 | 24/03/22 | R 13 Leones Negros UDEG 0 Raya2 Expansion 0 M06:05 | 31/03/22 | R 15 Tlaxcala FC 2 Raya2 Expansion 1 M05:05 | 08/04/22 | R 16 Raya2 Expansion 0 Tepatitlan FC 2 M18:00 | 10/04/22 | R 12 Raya2 Expansion 0 CSD Dorados Sinaloa 1 G01:00 | 16/04/22 | R 17 CD Tapatio 1 Raya2 Expansion 2 |
| 16 | |  Pumas de Tabasco | 16 | 2 | 6 | 8 | 13 | 25 | -12 | 12 | M02:00 | 18/03/22 | R 12 Tepatitlan FC 1 Pumas de Tabasco 0 B04:05 | 23/03/22 | R 13 Pumas de Tabasco 2 Cimarrones de Sonora FC 2 B04:00 | 26/03/22 | R 14 Cancun FC 2 Pumas de Tabasco 2 M04:05 | 31/03/22 | R 15 Pumas de Tabasco 1 CF Correcaminos UAT 2 B01:00 | 06/04/22 | R 16 Alebrijes de Oaxaca FC 0 Pumas de Tabasco 0 M03:05 | 14/04/22 | R 17 Pumas de Tabasco 0 Atletico Morelia 1 |
| 17 | |  Tampico Madero FC | 16 | 2 | 5 | 9 | 14 | 21 | -7 | 11 | M21:05 | 20/03/22 | R 12 Atletico Morelia 2 Tampico Madero FC 1 G06:05 | 24/03/22 | R 13 Tampico Madero FC 1 CD Mineros de Zacatecas 0 M06:00 | 28/03/22 | R 14 CF Correcaminos UAT 2 Tampico Madero FC 1 B03:00 | 02/04/22 | R 15 Leones Negros UDEG 1 Tampico Madero FC 1 B03:05 | 07/04/22 | R 16 Tampico Madero FC 2 Club Celaya FC 2 M01:00 | 13/04/22 | R 17 Tlaxcala FC 1 Tampico Madero FC 0 |
